iGene Cancer Panel
Cancer is a multifactorial disease with marked genetic etiologies. Germline mutations in high penetrance genes such as BRCA1, BRCA2, TP53, and PTEN are associated with multiple cancer syndromes. As each cancer site is often associated with multiple genes and hereditary cancer syndromes, an extensive test, screening multiple associated high-penetrance genes, serves as a powerful tool for determining a patient’s health management, especially when the patient has an extensive family history of cancer.
Covered Diseases / Risk Areas: 9 hereditary cancer syndromes: breast cancer, ovarian cancer, colorectal cancer, gastric cancer, pancreatic cancer, endometrial cancer, renal cell carcinoma, melanoma, and prostate cancer.
- Genes (20): APC, BMPR1A, BRCA1, BRCA2, CDH1, CDKN2A, MEN1, MLH1, MSH2, MSH6, MUTYH, NTRK1, PTCH1, PMS2, PTEN, RET, SMAD4, STK11, TP53, and VHL
- Test Code: 9001
• Confirmation in patients with differential diagnosis including various hereditary cancer syndromes.
• Diagnosis for patients with a complicated family history involving different types of cancer.
- Test Info Sheet: iGene Cancer Panel
- Requisitions: General Test Requisition Form
- Turn-Around Time: 4 Weeks
- Preferred Specimen: 3-5 mL Whole Blood – Lavender Top Tube
- Other Specimens: See details here
- CPT Codes: 81201×1, 81211×1, 81213×1, 81292×1, 81295×1, 81298×1, 81317×1, 81321×1, 81404×2, 81405×3, 81406×4, 81479×3
- Pricing: Please contact us at (949) 916-8886 or email@example.com
- Methodology: Next-Generation Sequencing (NGS)
- Related Tests:
Breast Cancer Panel
BRCA1 and BRCA2 Sequencing
1. “Leading Causes of Death”, http://www.cdc.gov/nchs/fastats/leading-causes-of-death.htm Cancers for Disease Control and Prevention.
2. Howlader N, et al. SEER Cancer Statistics Review, 1975-2013, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/ 1975 _2013/ based on November 2015 SEER data submission, posted to the SEER web site, April 2016.
3. National Cancer Institute at the National Institutes of Health. What you need to know about: cancer; risk factors. https://www.cancer.gov/about-cancer
4. National Comprehensive Cancer Network., Genetic/Familial High-Risk Assessment: Breast and Ovarian (Version 2.2017). https://www.nccn.org/professionals/physician_gls/pdf/genetics_screening.pdf. Accessed January, 2017
5. National Comprehensive Cancer Network. Colorectal Cancer Screening (Version 2.2016). https://www.nccn.org/professionals/physician_gls/pdf/colorectal_screening.pdf. Accessed January, 2017
6. National Comprehensive Cancer Network. Clinical Practice Guidelines in Oncology, Gastric Cancer (Version 3. 2016). https://www.nccn.org/professionals/physician_gls/pdf/gastric.pdf. Accessed January, 2017
7. National Comprehensive Cancer Network. Clinical Practice Guidelines in Oncology, Genetic/Familial High‐Risk Assessment: Colorectal (Version 2.2016). https://www.nccn.org/professionals/physician_gls/pdf/genetics_colon.pdf. Accessedy, 2017