Macular Degeneration Panel

Macular Degeneration Panel

  • Macular degeneration is a disorder of the retina, the light sensitive inner lining of the back of the eye. The macula is a small, central portion of the retina which is necessary for sharp, “straight ahead” vision needed for reading, driving a car, or recognizing faces (1). The disease can occur in one or both eyes and can progress slowly or quickly. Although individuals with the disease do not experience total blindness, the loss of central vision can significantly interfere with everyday activities (2). The prevalence of the disease is estimated to be between 1 in 2,000 people in the United States and other developed countries and currently affects several million Americans (3). An estimated 15 to 20 percent of people with age-related macular degeneration have at least one first-degree relative with the condition. Genetic testing is therefore highly recommended to assess risk for the affected individual and their family members.
  • Genes (22): ABCA4, APOE, ARMS2, C2, C3, CFB, CFH, CFI, CNGB3, CST3, CX3CR1, EFEMP1, ELOVL4, ERCC6, FBLN5, HMCN1, HTRA1, PRPH2, RAX2, RLBP1, RPGR, and TLR4
    Test Code: 6111
    Clinical Indications:
    • Molecular confirmation of a clinical diagnosis in symptomatic patients.
    • Assessment for at-risk family members
    Test Info Sheet: Macular Degeneration Panel
    Requisition: Contact ApolloGen Diagnostic Laboratory
  • Turn-Around Time: 4 Weeks
    Preferred Specimen: 3-5 mL Whole Blood – Lavender Top Tube
    Other Specimens: See details here
  • CPT Codes: 81401×1, 81404×1, 81405×1, 81408×1, 81479×18
    Pricing: Please contact us at (949) 916-8886 or inquiries@apollogen.com
  • Methodology: Next-Generation Sequencing (NGS)
    Related Tests:
    Eye Disorders Panel
  • References:
    1. http://www.djo.harvard.edu/site.php?url=/patients/pi/405
    2. http://www.brightfocus.org/macular/information
    3. https://ghr.nlm.nih.gov/condition/age-related-macular-degeneration#statistics

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