Migraines usually cause intense, throbbing pain in one area of the head that is often accompanied by nausea, vomiting, and extreme sensitivity to light and sound. They can be triggered by certain foods, emotional stress, and minor head trauma. Mutations in several genes have been found to implicated in the appearance of migraines. These genes… Read more »

Migraine Panel

  • Migraines usually cause intense, throbbing pain in one area of the head that is often accompanied by nausea, vomiting, and extreme sensitivity to light and sound. They can be triggered by certain foods, emotional stress, and minor head trauma. Mutations in several genes have been found to implicated in the appearance of migraines. These genes encode proteins that transport charged ions, or control signaling between neurons, or control neurotransmitter release (1). There are several medications that are available over the counter or by prescription to treat migraines. Up to 25% of people experience a migraine headache at some point in their life, but the majority of those affected are female with a male:female ratio of about 3:1 (2). Patients with migraines often have a well-defined family history of the disorder, and in these cases genetic testing is recommended as there seems to be a genetic predisposition.
  • Genes (23): ALDH7A1, ARX, ATP1A2, CACNA1A, CDKL5, ESR1, FOLR1, FOXG1, GAMT, KCNK18, KCNQ2, MECP2, NOTCH3, PCDH19, PHGDH, PNPO, POLG, PPT1, PRRT2, SCN1A, SLC2A1, STXBP1, and TNF
    Test Code: 5071
    Clinical Indications:
    • Molecular confirmation of a clinical diagnosis in symptomatic patients.
    • Assessment for at-risk family members
    Test Info Sheet: Migraine Panel
    Requisition: Contact ApolloGen Diagnostic Laboratory
  • Turn-Around Time: 4 Weeks
    Preferred Specimen: 3-5 mL Whole Blood – Lavender Top Tube
    Other Specimens: See details here
  • CPT Codes: 81302, 81404×2, 81405×2, 81406×7, 81407×1, 81479×10
    Pricing: Please contact us at (949) 916-8886 or inquiries@apollogen.com
  • Methodology: Next-Generation Sequencing (NGS)
    Related Tests:
    Epilepsy Panel
  • References:
    1. https://ghr.nlm.nih.gov/condition/familial-hemiplegic-migraine#diagnosis
    2. http://www.medicinenet.com/migraine/page2.htm#what_are_the_risk_factors_for_migraine

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