Pancreatic Cancer Panel

Pancreatic Cancer Panel

  • Pancreatic cancer is the fourth leading cause of cancer death in both men and women in the United States (1), where it accounts for about 3% of all cancers and about 7% of cancer deaths (2). Pancreatic cancer begins when cells in the pancreas start to grow uncontrollably. Signs and symptoms of include jaundice, dark urine, greasy stools, itchy skin, back or belly pain, weight loss and poor appetite, nausea and vomiting, blood clots, diabetes, and many more. Approximately 5-10% of pancreatic cancer patients report a family history of pancreatic cancer indicating that inherited genetic factors also play an important role. While the genetic basis for the majority of the familial clustering of pancreatic cancer remains unclear, several important pancreatic cancer genes have been identified (1, 3).
  • Genes (31): ACVR1B, APC, ATM, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, CDK4, CDKN2A, CHEK2, EPCAM, FANCC, MEN1, MLH1, MSH2, MSH6, NBN, NF1, PALB2, PALLD, PMS2, PRSS1, SMAD4, SPINK1, STK11, TP53, TSC1, TSC2, VHL, and XRCC2
    Test Code: 2035
    Clinical Indications:
    • Personal or family history suggestive of a predisposition to hereditary pancreatic cancer
    • Molecular confirmation of a clinical diagnosis in symptomatic patients.
    • Assessment for at-risk family members
    Test Info Sheet: Pancreatic Cancer Panel
    Requisition: Cancer Test Requisition Form
  • Turn-Around Time: 4 Weeks
    Preferred Specimen: 3-5 mL Whole Blood – Lavender Top Tube
    Other Specimens: See details here
  • CPT Codes: 81201×1, 81211×1, 81213×1, 81242×1, 81292×1, 81295×1, 81298×1, 81317×1, 81404×4, 81405×3, 81406×3, 81407×1, 81408×2, 81479×10
    Pricing: Please contact us at (949) 916-8886 or inquiries@apollogen.com
  • Methodology: Next-Generation Sequencing (NGS)
    Related Tests:
    BRCA1 and BRCA2 Sequencing
    Breast Cancer Panel
    iGene Cancer Panel (Comprehensive Hereditary Cancer Panel)
  • References:
    1. Klein, A. P. Genetic susceptibility to pancreatic cancer. Mol Carcinog 51, 14–24 (2012).
    2. http://www.cancer.org/cancer/pancreaticcancer/detailedguide/pancreatic-cancer-key-statistics
    3. http://www.cancer.org/acs/groups/cid/documents/webcontent/003131-pdf.pdf

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