Prostate Cancer Panel

Prostate Cancer Panel

  • Prostate cancer is the development of cancer in the prostate gland in the male reproductive system. Aside from skin cancer, prostate cancer is the most common cancer in American men; approximately 220,000 new cases are identified each year. Prostate cancer is also the second leading cause of cancer death in American men; lung cancer being first. It is estimated that about 1 out of every 7 men will be diagnosed with prostate cancer during his lifetime (1), and that the likelihood of getting prostate cancer will increase with age (2). Men with a father or brother who has developed prostate cancer are twice as likely to develop the disease (2) indicating that inherited DNA changes in certain genes are associated with the development of about 5-10% of prostate cancers (3). Although no single gene is responsible for prostate cancer, many different mutations in various genes have been implicated. Mutations in BRCA1 and BRCA2, known to be important risk factors for ovarian and breast cancer, also account for a small percentage of prostate cancers. Studies done on other genes such as CHEK2, NBN, and TP53 have also found a link between these genes and prostate cancer (4, 5, 6). Genetic testing and evaluation of mutations can help manage risk for the affected individuals as well as their families (7).
  • Genes (12): BRCA1, BRCA2, CDH1, CDKN1C, CHEK2, EPCAM, MLH1, MSH2, MSH6, NBN, PMS2, and TP53
    Test Code: 2031
    Clinical Indications:
    • Molecular confirmation of a clinical diagnosis in symptomatic patients
    • Assessment for at-risk family members
    Test Info Sheet: Prostate Cancer Panel
    Requisition: Cancer Test Requisition Form
  • Turn-Around Time: 4 Weeks
    Preferred Specimen: 3-5 mL Whole Blood – Lavender Top Tube
    Other Specimens: See details here
  • CPT Codes: 81211×1, 81213×1, 81292×1, 81295×1, 81298×1, 81317×1, 81405×1, 81406×1, 81479×4
    Pricing: Please contact us at (949) 916-8886 or inquiries@apollogen.com
  • Methodology: Next-Generation Sequencing (NGS)
    Related Tests:
    BRCA1 and BRCA2 Sequencing
    Breast Cancer Panel
    iGene Cancer Panel (Comprehensive Hereditary Cancer Panel)
  • References:
    1. http://www.cancer.org/cancer/prostatecancer/detailedguide/prostate-cancer-key-statistics
    2. http://www.pcf.org/site/c.leJRIROrEpH/b.5802027/k.D271/Prostate_Cancer_Risk_Factors.htm
    3. http://www.cancer.org/cancer/prostatecancer/detailedguide/prostate-cancer-what-causes
    4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC379222/
    5. http://www.ncbi.nlm.nih.gov/pubmed/23149842
    6. http://www.ncbi.nlm.nih.gov/pubmed/20592345
    7. http://prostatecanceruk.org/about-us/news-and-views/2015/7/prostate-cancer-in-your-genes-what-can-genetic-testing-tell-us

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