Pulmonary Hypertension Panel

Pulmonary Hypertension Panel

  • Pulmonary hypertension (PH) manifests itself as high blood pressure in the arteries of the lungs that is caused by the hardening and narrowing of blood vessels that carry blood from the heart to the lungs. This blood vessel hardening process can lead to weakening of the heart and eventually to heart failure. Symptoms include shortness of breath, tiredness, chest pain, a racing heartbeat, pain on the upper right side of the abdomen, and decreased appetite (1). Treatment for PH can include oxygen, diuretics, blood thinners, medications that open the pulmonary arteries, and treatments for any underlying disease (2). There are approximately 1,000 new cases of PH that are diagnosed each year in the US and the disorder is twice as common in females as in males (3). Inherited cases of the disorder are often characterized by an autosomal dominant pattern of inheritance, meaning that only one copy of an altered gene in each cell is sufficient to cause the disorder. Genetic testing is highly recommended to assess the risk for affected individuals and their family members (3).
  • Genes (9): ACVRL1, BMPR2, CAV1, CPS1, ENG, FOXF1, KCNK3, SARS2, and SMAD9
    Test Code: 3041
    Clinical Indications:
    • Molecular confirmation of a clinical diagnosis in symptomatic patients
    • Assessment for at-risk family members
    Test Info Sheet: Pulmonary Hypertension Panel
    Requisition: Cardiac Test Requisition Form
  • Turn-Around Time: 4 Weeks
    Preferred Specimen: 3-5 mL Whole Blood – Lavender Top Tube
    Other Specimens: See details here
  • CPT Codes: 81406×2, 81479×7
    Pricing: Please contact us at (949) 916-8886 or inquiries@apollogen.com
  • Methodology: Next-Generation Sequencing (NGS)
    Related Tests:
    Pan-Cardio Panel
  • References:
    1. https://www.nlm.nih.gov/medlineplus/pulmonaryhypertension.html
    2. http://www.medicinenet.com/pulmonary_hypertension/article.htm
    3. https://ghr.nlm.nih.gov/condition/pulmonary-arterial-hypertension#resources

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