Sudden Death Syndrome Panel

Sudden Death Syndrome Panel

  • Sudden death syndrome comprises genetic heart conditions that can cause sudden death in young, apparently healthy, people. The warning signs of the syndrome include a family history of unexpected and unexplained sudden death under the age of 40, fainting or seizure during exercise or excitement, and consistent or unusual chest pain or shortness of breath during exercise. The condition can be passed down from parent to child with each child of an affected parent having a 50% chance of inheriting the condition (1). Certain medication and treatments are available for the symptoms and the earlier the diagnosis the better. Genetic testing is highly recommended to assess risks among the affected individual and their family members (2, 3).
  • Genes (68): AKAP9, ANK2, CACNA1C, CACNB2, CALR3, CASQ2, CAV3, CSRP3, CTF1, DES, DSC2, DSG2, DSP, DTNA, EYA4, FBN1, FBN2, FKTN, GJA5, GPD1L, JPH2, JUP, KCNA5, KCNE1, KCNE2, KCNE3, KCNH2, KCNJ2, KCNQ1, LAMP2, LDB3, LMNA, LRP6, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYLK2, MYOZ2, NEXN, NPPA, PKP2, PLN, PRKAG2, PSEN1, PSEN2, RBM20, RYR2, SCN1B, SCN3B, SCN4B, SCN5A, SGCD, SLC25A4, SNTA1, TAZ, TCAP, TGFB3, TGFBR2, TMEM43, TMPO, TNNC1, TNNI3, TNNT2, TPM1, TTN, and VCL
    Test Code: 3045
    Clinical Indications: Family history suggestive of Sudden Death Syndrome
    Test Info Sheet: Sudden Death Syndrome Panel
    Requisition: Cardiac Test Requisition Form
  • Turn-Around Time: 4 Weeks
    Preferred Specimen: 3-5 mL Whole Blood – Lavender Top Tube
    Other Specimens: See details here
  • CPT Codes: 81403×2, 81404×3, 81405×11, 81406×16, 81407×4, 81408×2, 81479×30
    Pricing: Please contact us at (949) 916-8886 or inquiries@apollogen.com
  • Methodology: Next-Generation Sequencing (NGS)
    Related Tests:
    Comprehensive Cardiomyopathy Panel
    Dilated Cardiomyopathy Panel
    Hypertrophic Cardiomyopathy Panel
    Familial Hypercholesterolemia Panel
    Arrhythmias Panel
    Long QT Syndrome Panel
  • References:
    1. http://www.sads.org/What-is-SADS#.V317zFUrKUk
    2. http://www.sads.org.uk/family-implications/
    3. Fernandez-Falgueras, A., Sarquella-Brugada, G., Brugada, J., Brugada, R. & Campuzano, O. Cardiac Channelopathies and Sudden Death: Recent Clinical and Genetic Advances. Biology (Basel) 6, (2017).

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